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. 2021 Apr 16;9:649830. doi: 10.3389/fcell.2021.649830

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Copyright © 2021 Landin Malt, Clancy, Hwang, Liu, Smith, Smith, Hatley, Clemens and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Non-canonical Wnt and PCP pathways act in concert to regulate cochlear morphogenesis. (A) A working model for the concerted actions of the non-canonical Wnt and PCP pathways in regulating different aspects of cochlear morphogenesis. (B) Schematic diagrams comparing PCP defects in the Wls^cKO and core PCP mutant OC. Kinocilium (the red dot) positioning at the hair bundle vertex was disrupted in Wls^cKO but not core PCP mutants.