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. 2021 Apr 16;12:649475. doi: 10.3389/fimmu.2021.649475

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Copyright © 2021 Etna, Severa, Licursi, Pardini, Cruciani, Rizzo, Giacomini, Macchia, Palumbo, Stallone, Carella, Livingstone, Negri, Pellegrini and Coccia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene ontology analysis of genes regulated/modulated in transcriptome and in translatome of human DC infected with Mtb alone or in presence of rapamycin. Top 20 gene ontology (GO) terms within the biological process (BP) branch emerged from the list of genes found de-regulated (log2 FC > 1.5; FDR < 0.01) in transcriptome (A) (blue panels) and translatome (B) (red panels) of human DC infected with Mtb (MTB) and treated with rapamycin (MTB+RAPA). Relevant BP have been graphed by using the formula -log₁₀ of their Benjamini-Hochberg false discovery rate adjusted p-values. The numbers next to BP name, represent the total number of genes that may be significantly involved in the corresponding biological processes. The graph displays the classification term enrichment status and term hierarchy.