Table 1.
List of top genes de-regulated at the translatome level in human DC after Mtb infection and rapamycin treatment.
| GENES UP-REGULATED BY RAPAMYCIN IN MTB-INFECTED DC AT TRANSLATOME LEVEL | |||||
|---|---|---|---|---|---|
| Gene ID | Gene Name | Translatome log2 FC | Transcriptome log2 FC | ||
| MTB | MTB+RAPA | MTB | MTB+RAPA | ||
| NM_005409 | CXCL11 | 6.28 | 7.54 | 5.61 | 5.40 |
| NM_052941 | GBP4 | 5.31 | 6.14 | 4.76 | 5.06 |
| NM_0011300 | CCL20 | 4.69 | 5.73 | 3.64 | 4.77 |
| NM_001838 | CCR7 | 4.20 | 5.31 | 3.38 | 4.02 |
| NM_001547 | IFIT2 | 4.91 | 5.28 | 4.57 | 4.44 |
| NM_002416 | CXCL9 | 4.32 | 5.04 | 3.73 | 3.75 |
| NM_001031 | IFIT3 | 4.47 | 4.72 | 4.33 | 4.11 |
| NM_001134 | GBP5 | 3.51 | 4.31 | 3.48 | 4.19 |
| NM_002981 | CCL1 | 2.60 | 4.29 | 4.20 | |
| NM_022168 | IFIH1 | 3.63 | 4.24 | 3.60 | 3.59 |
| NM_000856 | GUCY1A3 | 2.97 | 1.71 | ||
| NM_004120 | GBP2 | 2.05 | 2.86 | 1.81 | 2.55 |
| NM_002176 | IFNB1 | 1.78 | 2.75 | 1.84 | |
| NM_172140 | IFNL1 | 1.59 | 2.35 | 1.50 | 1.65 |
| NM_000857 | GUCY1B3 | 2.04 | |||
| NM_004031 | IRF7 | 1.69 | |||
| NM_024013 | IFNA1 | 1.53 | |||
| GENES DOWN-REGULATED BY RAPAMYCIN IN MTB-INFECTED DC AT TRANSLATOME LEVEL | |||||
| Gene ID | Gene Name | Translatome log2 FC | Transcriptome log2 FC | ||
| MTB | MTB+RAPA | MTB | MTB+RAPA | ||
| NM_003246 | THBS1 | 3.67 | 2.94 | 3.02 | 2.95 |
| NM_0011357 | TP53INP1 | -2.23 | -1.50 | ||
| NM_001005 | TRIM37 | -1.62 | |||
| NM_003544 | HIST1H4B | -1.94 | |||
| NM_006068 | TLR6 | -2.39 | -2.86 | -1.50 | |
| NM_001237 | CCNA2 | -3.26 | |||
| NM_003537 | HIST1H3B | -4.09 | |||
List of top genes showing a statistically significant modulation at translatome level in Mtb-infected DC in presence or absence of rapamycin, with respect to uninfected DC.
FC, fold change; MTB, Mtb-infected DC; MTB+RAPA, Mtb-infected DC treated with rapamycin; CXCL11, C-X-C motif chemokine 11; GBP4, Guanylate Binding protein 4; CCL20, Chemokine (C-C motif) ligand 20; CCR7, C-C Chemokine receptor type 7; IFIT2, Interferon Induced Protein With Tetratricopeptide Repeats 2; CXCL9, C-X-C Motif Chemokine Ligand 9; IFIT3, Interferon Induced Protein With Tetratricopeptide Repeats 3; GBP4, Guanylate Binding protein 5; CCL1, Chemokine (C-C motif) ligand 1; IFIH1, Interferon Induced With Helicase C Domain 1; GUCY1A3, Guanylate cyclase soluble subunit alpha-3; GBP2, Guanylate Binding protein 2; IFNB1, Interferon beta; IFNL1, Interferon lambda 1; GUCY1B3, Guanylate cyclase soluble subunit beta-3; IRF7, Interferon regulatory factor 7; IFNA1, Interferon alfa 1; THBS1, Thrombospondin 1; TP53INP1, Tumor Protein P53 Inducible Nuclear Protein 1; TRIM37, Tripartite Motif Containing 37; HIST1H4B, H4 Clustered Histone 2; TLR6, Toll-like receptor 6; CCNA2, Cyclin A2; HIST1H3B, H3 Clustered Histone 2.