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. Author manuscript; available in PMC: 2021 Nov 12.
Published in final edited form as: J Med Chem. 2020 Oct 23;63(21):13103–13123. doi: 10.1021/acs.jmedchem.0c01520

Figure 3.

Figure 3.

Inhibition of β5i and β5c by select dipeptides. A) Dose-dependent inhibition of β5i and β5c by compounds indicted in the x-axial. B) Ki of PKS21265 was also determined with varying concentrations of PKS21265 and substrate suc-LLVY-AMC. Lineweaver-Burk plot was shown on the left. The plot of slopes against inhibitor concentration yield a Ki 3.1 nM.