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. Author manuscript; available in PMC: 2021 Nov 12.
Published in final edited form as: J Med Chem. 2020 Oct 23;63(21):13103–13123. doi: 10.1021/acs.jmedchem.0c01520

Scheme 4.

Scheme 4.

Reagents and conditions: a) tert-butylamine, EDC, HOBt, Hünig’s base; b) TFA, DCM; c) 3-phenylpropanoic acid, HATU, HOAt, Hünig’s base, DMF; d) 10% Pd on carbon, methanol, hydrogen balloon; e) triethylamine, DCM; f) HATU, HOAt, Hünig’s base, DMF