Table 1.
Concentrations of [D10]Phe metabolites in 6-h urine (nmol/6-h urine)
| [D10]Phe metabolites | ||||
|---|---|---|---|---|
| [D10]1,2-PheD | [D10]PheT | Total [D9]OHPhe | ||
| Non-smokers (1 μg dose, N = 57) | Mean (range) | 0.39 (ND ~1.61) | 0.11 (0.02–0.25) | 0.28 (0.05–1.55) |
| SD | 0.40 | 0.06 | 0.23 | |
| CV (%) | 102 | 52.0 | 80.8 | |
| Median (25th, 75th) | 0.23 (0.12, 0.44) | 0.11 (0.07, 0.14) | 0.24 (0.15, 0.34) | |
| Smokers (1 μg dose, N = 35) | Mean (range) | 0.36 (ND ~1.29) | 0.14 (0.003–0.29) | 0.18 a(ND ~0.68) |
| SD | 0.33 | 0.07 | 0.14 | |
| CV (%) | 90.2 | 55.2 | 77.5 | |
| Median (25th, 75th) | 0.23 (0.14, 0.56) | 0.14 (0.07, 0.17) | 0.16 (0.07, 0.24) | |
| Smokers (10 μg dose, N = 135) | Mean (range) | 6.55 a(ND ~28.63) | 2.26 a(ND ~7.75) | 1.13 a(ND ~6.41) |
| SD | 4.37 | 1.67 | 0.75 | |
| CV (%) | 66.7 | 73.9 | 66.7 | |
| Median (25th, 75th) | 5.49 (3.29, 9.33) | 1.82 (0.88, 3.38) | 1.01 (0.65, 1.47) | |
aBolded values, P < 0.01 compared with non-smokers, Wilcoxon rank-sum test.
CV, coefficient of variation.