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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: JACC Cardiovasc Imaging. 2021 Mar 17;14(4):826–839. doi: 10.1016/j.jcmg.2021.01.007

Central Illustration: Sub-Papillary Ischemia is Associated with Functional Mitral Regurgitation.

Central Illustration:

Multicenter data from the SCMR registry demonstrated stress CMR evidenced LV ischemia underlying the mitral valve to be a key determinant of FMR. Extent of ischemic and dysfunctional LV myocardium in sub-papillary segments remained associated with FMR when controlling for LV infarction in corresponding territories or papillary muscle ischemia. During follow-up, mortality risk increased in proportion to severity of FMR: FMR severity remained associated with increased mortality even after adjustment for conventional prognostic indices and determinants of FMR (LV ischemia, infarction, dysfunction).