Skip to main content
. 2021 Apr 30;129(4):047014. doi: 10.1289/EHP7722

Figure 1.

Figure 1 is a schematic diagram of the Human Exposome and Metabolite Database establishment workflow having four steps. Step 1: Human Exposome and Metabolite Database with an icon of a database leads to Human Exposome and Metabolite Database graphical user interface with an icon of a laptop, Database and literature fusion, including U.S. Environmental Protection Agency, Centers for Disease Control and Prevention, U.S. Food and Drug Administration, National Institutes of Health, Exposome Explorer, Literature. The literature includes: disinfection by products; gut microbiome metabolites; air, dust, water; and mycotoxins. Step 2: Database and literature fusion leads to Systematic Empirical Evaluation of Models exposure prediction, where probabilistic hazard quotient equals estimated human exposure over toxicity data; Risk index equals exposure begin subscript normalized end subscript times Toxicological Priority Index score; and Toxicity Estimation Software Tool toxicity prediction per Toxicological Priority Index score. The literature with Iterative Fragment Selection method leads to half life prediction. Step 3: Systematic Empirical Evaluation of Models exposure prediction leads to risk-based prioritization and half life prediction with biotransformer, the Metabolomics innovation center leads to biotransformation metabolite prediction. Step 4: Biotransformation metabolite prediction leads to Candidate metabolite database with an icon of a database.

Schematic workflow for Human Exposome and Metabolite Database (HExpMetDB) establishment. Note: CDC, Centers for Disease Control and Prevention; FDA, U.S. Food and Drug Administration; GUI, graphical user interface; ISF, Iterative Fragment Selection; NIH, National Institutes of Health; PrHQ, probabilistic hazard quotient; RI, risk index; SEEM3, Systematic Empirical Evaluation of Models; TEST, Toxicity Estimation Software Tool; ToxPi, Toxicological Priority Index.