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. Author manuscript; available in PMC: 2021 Apr 30.
Published in final edited form as: J Pediatr. 2020 May 22;224:115–123.e2. doi: 10.1016/j.jpeds.2020.05.028

Figure 1.

Figure 1.

Mechanisms involved in increased arterial thickness and stiffness (central role of the RAS). ACE2, angiotensin-converting enzyme 2; Ang-(1–7), angiotensin-(1–7); AT1R, angiotensin II type 1 receptor; MasR, Mas receptor; NO, nitric oxide; TGF, transforming growth factor.