Table 3. Differences between CRBSIs caused by Gram-positive cocci and Gram-negative bacilli.
| GPC n = 357 (%) | GNB n = 110 (%) | p-value | |
|---|---|---|---|
| Age–Median (IQR) | 48 (35–59) | 54 (42–61) | 0.006 |
| Male | 221 (61.9) | 64 (57.7) | 0.437 |
| Hematological malignancy | 339 (95.0) | 102 (91.9) | 0.245 |
| Solid neoplasm | 31 (8.7) | 17 (15.3) | 0.050 |
| HSCT | 141 (39.5) | 28 (25.2) | 0.007 |
| Catheter culture | |||
| Positive | 138 (38.7) | 43 (38.7) | 0.219 |
| Negative | 47 (13.2) | 23 (20.7) | |
| Not performed | 172 (48.2) | 45 (40.9) | |
| Type of catheter | |||
| Femoral | 10 (2.8) | 1 (0.9) | <0.001 |
| Subclavian | 17 (4.9) | 9 (8.4) | |
| Jugular | 266 (76.9) | 60 (56.1) | |
| Port-a-cath | 17 (4.9) | 23 (21.5) | |
| PVC | 36 (10.4) | 14 (13.1) | |
| Days after catheter placement–Median (IQR) | 18 (11–40) | 24 (13–60) | 0.013 |
| Clinical presentation | |||
| Fever | 342 (96.6) | 105 (96.3) | 0.889 |
| Shock | 9 (2.5) | 11 (10.0) | 0.002 |
| Prior corticosteroid therapy | 124 (35.8) | 43 (41.7) | 0.276 |
| Prior antibiotic therapy | |||
| Beta-lactam | 93 (26.1) | 44 (39.6) | 0.006 |
| Penicilins± | 26 (7.0) | 22 (20.0) | <0.001 |
| Aminoglycoside | 27 (7.6) | 15 (13.5) | 0.055 |
| Glycopeptide | 37 (10.4) | 14 (12.6) | 0.507 |
| Fluoroquinolone | 118 (33.1) | 34 (30.6) | 0.634 |
| Current antibiotic therapy | |||
| Beta-lactam | 116 (32.5) | 37 (33.3) | 0.908 |
| Aminoglycoside | 30 (8.4) | 10 (9.0) | 0.842 |
| Glycopeptide | 45 (12.6) | 23 (20.7) | 0.034 |
| Fluoroquinolone | 175 (49.0) | 37 (33.3) | 0.004 |
| IEAT | 106 (29.7) | 22 (20) | 0.012 |
| Overall mortality | 19 (5.4) | 16 (14.4) | 0.002 |
| Related mortality | 13 (3.7) | 8 (7.2) | 0.124 |
GPC: Gram-positive cocci; GNB: Gram-negative bacilli; IQR: Interquartile range; HSCT: Hematopoietic stem-cell transplant; PVC: Peripheral venous catheter; IEAT: Inappropriate empirical antibiotic treatment.
±Consisting of piperacillin-tazobactam, amoxicillin, ampicillin, amoxicillin-clavulanate and cloxacillin