Table 5. Most frequent microbiological isolates associated with inappropriate antibiotic therapy and high mortality.
| Microorganism | n | IEAT n (%) | Mortality in IEAT n (%) | Mortality in AEAT n (%) | Overall mortality n (%) | p-value |
|---|---|---|---|---|---|---|
| Gram-positive (GPC) | 357 | 106 (30.1) | 12 (5) | 7 (6.2) | 19 (5.4) | 0.649 |
| S. aureus | 17 | 2 (11.8) | 1 (50.0) | 2 (13.3) | 3 (17.6) | 0.331 |
| MRSA | 4 | 2 (50.0) | 1 (50) | 0 | 1 (25.0) | 1.000 |
| CoNS | 310 | 101 (32.9) | 6 (5.9) | 8 (3.9) | 14 (4.5) | 0.433 |
| Enterococcus spp. | 16 | 4 (25.0) | 0 | 2 (16.7) | 2 (12.5) | 1.000 |
| E.faecium | 8 | 2 (25.0) | 0 | 2 (33.3) | 2 (25.0) | 1.000 |
| Gram-negative (GNB) | 110 | 22 (20.0) | 6 (27.3) | 9 (10.2) | 15 (13.6) | 0.037 |
| E. coli | 29 | 1 (3.4) | 0 | 4 (14.3) | 4 (13.8) | 1.000 |
| ESBL | 8 | 1 (12.5) | 0 | 3 (42.9) | 3 (37.5) | 1.000 |
| P. aeruginosa | 36 | 9 (25.0) | 3 (33.3) | 2 (7.4) | 5 (13.9) | 0.088 |
| MDR | 13 | 9 (69.2) | 3 (33.3) | 1 (25) | 4 (30.8) | 1.000 |
| K. pneumoniae | 9 | 0 | 0 | 1 (11.1) | 1 (11.1) | - |
| ESBL | 3 | 0 | 0 | 0 | 0 | - |
| S. maltophilia | 14 | 11 (78.6) | 3 (27.3) | 1 (33.3) | 4 (28.6) | 1.000 |
IEAT: Inappropriate empirical antibiotic treatment; AEAT: Appropriate empirical antibiotic treatment; MRSA: Methicillin-resistant Staphylococcus aureus; CoNS: Coagulase-negative Staphylococci; ESBL: Extended-spectrum beta-lactamase; MDR: Multidrug-resistant; XDR: Extremely drug-resistant.