Table 1. ENc values across coronavirus genera.

Effective Number of Codons (ENc) for coronaviruses, stratified by genus and genome sequence type. ENc values are calculated as grand means, i.e., mean ENc was calculated per coronavirus by averaging sequences before means of means were calculated per genus by averaging coronaviruses. SD denotes standard deviation.

	Spike protein sequences		Whole genome sequences
Genus	Mean	SD	Mean	SD
Alphacoronavirus	48.65	3.12	45.02	3.00
Betacoronavirus	47.77	5.04	47.03	4.79
Gammacoronavirus	46.36	1.83	46.11	0.74
Deltacoronavirus	54.79	3.43	51.75	3.22
(unclassified)	47.89	3.41	48.56	3.04
total	48.77	4.36	46.81	4.22