Table 1.
Descriptive demographics of study populations stratified by eGFRs
| Variables | Group 1 (n = 22 130) |
Group 2 (n = 58 422) |
Group 3 (n = 138 942) |
Group 4 (n = 113 245) |
Group 5 (n = 140 424) |
Group 6 (n = 57 329) |
Group 7 (n = 34 097) |
P-value |
|---|---|---|---|---|---|---|---|---|
| Age (years), n (%) | ||||||||
| 45–49 | 4844 (21.9) | 12 976 (22.2) | 28 895 (20.8) | 26 964 (23.8) | 31 210 (22.2) | 11 655 (20.3) | 7222 (21.2) | <0.0001 |
| 50–54 | 4815 (21.8) | 13 463 (23.0) | 36 581 (26.3) | 27 165 (24.0) | 43 052 (30.7) | 15 100 (26.3) | 12 534 (36.8) | |
| 55–59 | 4873 (22.0) | 12 415 (21.3) | 26 571 (19.1) | 20 172 (17.8) | 19 405 (13.8) | 8864 (15.5) | 2235 (6.6) | |
| 60–64 | 2343 (10.6) | 7569 (13.0) | 20 108 (14.5) | 13 816 (12.2) | 22 551 (16.1) | 10 475 (18.3) | 6693 (19.6) | |
| 65–69 | 2580 (11.7) | 5410 (9.3) | 9763 (7.0) | 10 579 (9.3) | 9217 (6.6) | 3350 (5.8) | 1293 (3.8) | |
| 70–74 | 1357 (6.1) | 3715 (6.4) | 10 791 (7.8) | 9467 (8.4) | 9965 (7.1) | 6166 (10.8) | 3238 (9.5) | |
| ≥75 | 1318 (6.0) | 2874 (4.9) | 6233 (4.5) | 5082 (4.5) | 5024 (3.6) | 1719 (3.0) | 882 (2.6) | |
| Sex (male), n (%) | 11 488 (51.9) | 29 920 (51.2) | 72 199 (52.0) | 55 790 (49.3) | 73 579 (52.4) | 29 205 (50.9) | 17 458 (51.2) | <0.0001 |
| Smoking, n (%) | ||||||||
| None | 14 161 (64.0) | 37 619 (64.4) | 87 813 (63.2) | 72 690 (64.2) | 86 112 (61.3) | 35 285 (61.6) | 20 832 (61.1) | <0.0001 |
| Ex-smoker | 4330 (19.6) | 10 955 (18.8) | 26 621 (19.2) | 20 183 (17.8) | 25 780 (18.4) | 9703 (16.9) | 5354 (15.7) | |
| Current smoker | 3639 (16.4) | 9848 (16.9) | 24 508 (17.6) | 20 372 (18.0) | 28 532 (20.3) | 12 341 (21.5) | 7911 (23.2) | |
| Drinking, n (%) | ||||||||
| None | 14 161 (64.0) | 37 619 (64.4) | 87 813 (63.2) | 72 690 (64.2) | 86 112 (61.3) | 35 285 (61.6) | 20 832 (61.1) | <0.0001 |
| Moderate | 4330 (19.6) | 10 955 (18.8) | 26 621 (19.2) | 20 183 (17.8) | 25 780 (18.4) | 9703 (16.9) | 5354 (15.7) | |
| Heavy | 3639 (16.4) | 9848 (16.9) | 24 508 (17.6) | 20 372 (18.0) | 28 532 (20.3) | 12 341 (21.5) | 7911 (23.2) | |
| Physical activity, n (%) | 5036 (22.8) | 13 627 (23.3) | 32 648 (23.5) | 25 897 (22.9) | 32 042 (22.8) | 12 774 (22.3) | 7072 (20.7) | <0.0001 |
| Low income, n (%) | 4843 (21.9) | 12 143 (20.8) | 28 129 (20.3) | 23 195 (20.5) | 27 630 (19.7) | 11 730 (20.5) | 7473 (21.9) | <0.0001 |
| BMI, n (%) | ||||||||
| <18.5 | 368 (1.7) | 1008 (1.7) | 2664 (1.9) | 2658 (2.4) | 3364 (2.4) | 1662 (2.9) | 1249 (3.7) | <0.0001 |
| 18.5–22.9 | 6636 (30.0) | 19 017 (32.6) | 47 897 (34.5) | 41 275 (36.5) | 53 454 (38.1) | 22 597 (39.4) | 14 020 (41.1) | |
| 23.0–24.9 | 5962 (26.9) | 16 084 (27.5) | 38 898 (28.0) | 31 260 (27.6) | 38 282 (27.3) | 15 193 (26.5) | 8699 (25.5) | |
| 25.0–29.9 | 8116 (36.7) | 20 114 (34.4) | 45 034 (32.4) | 34 641 (30.6) | 41 260 (29.4) | 16 110 (28.1) | 9063 (26.6) | |
| ≥30 | 1048 (4.7) | 2199 (3.8) | 4449 (3.2) | 3411 (3.0) | 4064 (2.9) | 1767 (3.1) | 1066 (3.1) | |
| Waist circumference (cm) | 82.3 ± 8.9 | 81.9 ± 8.7 | 81.6 ± 8.5 | 81.2 ± 8.5 | 81.1 ± 8.5 | 81.0 ± 8.5 | 80.5 ± 8.7 | <0.0001 |
| SBP (mmHg) | 125.6 ± 15.7 | 124.6 ± 15.1 | 124.1 ± 14.9 | 123.7 ± 14.9 | 123.6 ± 14.9 | 124.1 ± 15.0 | 123.9 ± 15.3 | <0.0001 |
| DBP (mmHg) | 77.3 ± 10.4 | 77.3 ± 10.0 | 76.9 ± 9.9 | 76.5 ± 9.9 | 76.6 ± 10.0 | 76.6 ± 10.2 | 76.5 ± 10.5 | <0.0001 |
| Glucose (mg/dL) | 102.1 ± 28.4 | 100.1 ± 23.8 | 99.5 ± 22.8 | 99.1 ± 22.8 | 99.3 ± 23.5 | 99.6 ± 24.8 | 100.0 ± 25.9 | <0.0001 |
| Total cholesterol (mg/dL) | 198.8 ± 39.6 | 201.3 ± 37.6 | 200.5 ± 36.9 | 199.5 ± 36.4 | 198.5 ± 36.3 | 197.0 ± 36.2 | 195.2 ± 36.7 | <0.0001 |
| Triglycerides (mg/dL), median (IQR) | 125.8 (124.9–126.7) | 119.4 (118.9–120.0) | 116.9 (116.6–117.3) | 114.7 (114.4–115.1) | 114.1 (113.8–114.4) | 112.1 (111.6–112.6) | 111.4 (110.8–112.1) | <0.0001 |
| HDL (mg/dL) | 51.8 ± 13.8 | 53.2 ± 13.7 | 53.6 ± 13.6 | 54.1 ± 13.8 | 54.3 ± 14.1 | 54.6 ± 14.2 | 55.0 ± 14.6 | <0.0001 |
| LDL (mg/dL) | 117.6 ± 35.9 | 120.8 ± 34.5 | 120.2 ± 34.0 | 119.3 ± 33.6 | 118.1 ± 33.4 | 116.6 ± 33.3 | 114.5 ± 34.0 | <0.0001 |
| eGFR (mL/min/1.73 m2) | 50.6 ± 17.8 | 68.9 ± 7.2 | 81.0 ± 7.8 | 93.2 ± 7.5 | 99.2 ± 6.1 | 103.6 ± 6.3 | 110.9 ± 7.5 | <0.0001 |
| CCI score | 1.3 ± 1.6 | 0.9 ± 1.3 | 0.9 ± 1.2 | 0.9 ± 1.2 | 0.8 ± 1.2 | 0.9 ± 1.3 | 0.9 ± 1.2 | <0.0001 |
Values are presented as mean ± SD unless stated otherwise.
SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL, high-density lipoprotein; LDL, low-density lipoprotein; CCI, Charlson Comorbidity Index.