Fig. 1.

Leishmania parasites and locations of potential sensors. A. Insect stage promastigotes have an extended cell body and a long flagellum that exits from the flagellar pocket. B. Intracellular amastigotes have on oval-shaped cell body and a short flagellum that barely emerges from the flagellar pocket. In both life cycle stages, membrane bound sensors could be located at the distal tip of the flagellum (red sphere), along the length of the flagellum (purple sphere), or on the cell body membrane (green sphere), and other sensors could be cytosolic proteins (blue sphere). C. A cross section of the flagellum shows the surrounding flagellar membrane and an integral membrane protein (purple) representing a putative flagellar sensor. Other components of all images are as labeled. This figure was prepared by Laramie Studio, Portland, OR.