Fig. 3.

Import and export of iron and heme in Leishmania amazonensis. Lipid bilayers representing the plasma membrane are indicated at the top and bottom with the cytosol in between, and the mitochondrion is indicated in brown. LFR1 is an extracellularly oriented iron reductase that converts Fe³⁺ to Fe²⁺ at the parasite surface, generating the substrate for the iron permeases. Transporters for import (LIT1) or export (LIR1) of Fe²⁺ across the plasma membrane, for import of Fe²⁺ across the mitochondrial inner membrane (MIT1), and for import of heme across the plasma membrane (LHR1 and FLVCRb) are indicated as either ovals or a circle of different colors. Arrows indicate the direction of transport. Figure created with BioRender.com.