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. Author manuscript; available in PMC: 2021 Sep 25.
Published in final edited form as: Nat Immunol. 2021 Mar 25;22(4):423–433. doi: 10.1038/s41590-021-00898-1

Extended Data Fig. 4. The effect of metformin on NLRX1 expression in CD4 T cells.

Extended Data Fig. 4

a–d. CD3/CD28 antibody-activated human primary CD4 T cells were left uninfected (a) or infected by three different HIV-1 clinical isolates, #409 (b), #413 (c), and #414 (d) in the presence of 5 mM metformin or the vehicle control, sterile water. NLRX1 transcripts were assessed at 48 hpi by qPCR.

Representative data of three independent experiments are shown as the mean ± standard deviation (s.d). n = 4 cell cultures per experiment. Statistical significance was tested by two-tailed unpaired Student’s t-test.