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. 2021 May 3;131(9):e142088. doi: 10.1172/JCI142088

Figure 5. Antibody is detectable during the tissue-based immune response to HSV-2 reactivation, and the amount is variable over time.

Figure 5

(A) Immunofluorescence detection of IgG (green) in genital skin biopsies in 1 participant. Scale bars: 250 μm. Brightness has been increased for visualization; results shown for 1 of 10 participants. (B) Spatial localization of in-tissue IgG versus HSV antigen by IF in biopsy of an active HSV-2 lesion (different subject). Antigen is seen in multiple locations, with the highest density of IgG at the site of vesicle formation. Scale bars: 250 μm. The distribution of IgG and HSV antigen across multiple sites of viral involvement was unique to this specimen.