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. 2021 May 3;131(9):e144864. doi: 10.1172/JCI144864

Figure 5. An LKGGG CDR3β TCR crossreactive to CCL4 and PLXNA4 peptides.

Figure 5

(A) Set of CCL4 and PLXNA4 WT (red) and variant peptides that differed at the p4 and p6 positions. Colors highlight D5E8 and amino acids that vary at p4 and p6. (B) IL-2 production by hybridomas 8845-c1 (top) and AV22 (bottom) in response to CCL4 and PLXNA4 WT and variant peptides presented by HLA-DP2–transfected fibroblasts at 300 ng/mL in the presence of BeSO4. Data were normalized to WT peptides (CCL4 for 8845-c1; PLXNA4 for AV22) and are representative of 2 experiments done in duplicate.