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. Author manuscript; available in PMC: 2021 Apr 30.
Published in final edited form as: J Toxicol Environ Health A. 2020 Feb 5;83(2):45–65. doi: 10.1080/15287394.2020.1723154

Table 2:

Mean clinical severity score and duration of neurobehavioral signs slopes by treatment groupa

Clinical severity scores (points/d) Duration neurobehavioral signs (min/d)
Slope both sexes Slope males Slope females Slope both sexes Slope males Slope females
Imidacloprid dose
0.00 mg/kg/d 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00
0.03 mg/kg/d 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00
0.34 mg/kg/d −0.01 ± 0.02 −0.01 ± 0.03 0.00 ± 0.00 −0.27 ± 1.20 −0.54 ± 1.69 0.00 ± 0.00
3.42 mg/kg/d −0.07 ± 0.15 −0.04 ± 0.11 −0.10 ± 0.18 −0.42 ± 4.69 −0.30 ± 5.05 −0.54 ± 4.57
10.25 mg/kg/d −0.01 ± 0.08 −0.01 ± 0.07 −0.01 ± 0.09 1.46 ± 12.67 −1.11 ± 12.90 4.03 ± 12.54
15.50 mg/kg/d −0.10 ± 0.10*^ −0.05 ± 0.08 −0.15 ± 0.10^ −6.55 ± 9.51* −2.33 ± 10.09 −10.76 ± 7.05*~
a

A linear regression line was fitted for the clinical severity scores and the change in duration of neurobehavioral signs in each individual domestic chicken after oral imidacloprid exposure over the 7 day exposure period. The slope of the liner regression line was a representation of how an individual changed over time. The individual bird slope values were used to calculate a treatment group mean slope ± standard deviation of the clinical severity scores and duration of neurobehavioral signs. The treatment group mean slope is presented in this table. A Wilcoxon signed-rank test was performed within each treatment group to test if the slope values were significantly different from zero. A Kruskal-Wallis test was performed to compare the mean slope between treatment groups.

*

Slope was significantly different from zero p ≤ 0.01

^

Slope is significantly different than the 10.25 mg/kg/d group p ≤ 0.04

~

Slope is significantly different than the 3.42 and 10.25 mg/kg/d groups p ≤ 0.018