Figure 7.

Comparison of the HDL association t-statistics from RF and EN models trained in the MESA ALL cohort

Comparison of RF and EN t-statistics from the TWAS of HDL and predicted transcriptome in MESA individuals not used for imputation model building. Each dot in plot represents the t-statistic value of a gene from the HDL TWAS, while the identity line (slope = 1) is shown in blue. We see that the t-statistic values are similar between RF and EN except for genes that are unique in each algorithm shown as red dots in the plot. CETP is strongly associated with HDL levels using both EN- and RF-trained models. RF-trained models revealed the unique gene ST8SIA4 (no prediction model in EN) may be potentially associated with HDL levels (p = 4.3 × 10⁻³).