Table 4.
Odds Ratios for Pairwise Treatment Comparisons of Frail or Prefrail vs Nonfrail, Adjusted for Study Visit, in the Diabetes Prevention Outcomes Study (DPPOS)
| Outcome | Treatment | Reference | Odds Ratio | 95% Confidence Interval |
|---|---|---|---|---|
| Frail vs nonfrail | Lifestyle | Metformin* | 0.629 | 0.420–0.942 |
| Lifestyle | Placebo* | 0.625 | 0.419–0.934 | |
| Metformin | Placebo | 0.994 | 0.694–1.424 | |
| Prefrail vs nonfrail | Lifestyle | Metformin | 1.058 | 0.893–1.254 |
| Lifestyle | Placebo | 1.093 | 0.924–1.292 | |
| Metformin | Placebo | 1.033 | 0.873–1.221 |
Notes: Odds ratios are calculated using generalized estimating equations (GEE) with data from Years 8 and 10 pooled and treated as repeated measures.
*p < .05.