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. 2020 Sep 30;76(5):770–777. doi: 10.1093/gerona/glaa248

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© The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Figure 1. — Comparison of injury and resolution patterns in aged and adult mice. (A) Aged and adult mice underwent alveolar lavage under sham and ALI conditions. Adult mice had a significantly higher BAL cell count at peak inflammation but similar counts at all other time points (group size 4–10 per time point). (B) BAL protein levels were measured in aged and adult mice. Protein levels were similar at all time points (group size 3–6 per time point). (C) Aged mice had prolonged alveolar neutrophilia compared to adult mice. BAL neutrophil percentage was similar at peak inflammation but increased in aged mice at day 5 (group size 4–10 per time point). (D) IT-LPS results in robust systemic and alveolar TNFα production. Aged and adult mice have similar TNFα levels in both BAL and blood after lung injury (group size 4–6). (E, F) Aged mice exhibit resistance to exercise. Exercise reduces alveolar cell count (group size 8–11) and plasma G-CSF (group size 4–5) in adult but not aged mice after lung injury.