Figure 1.

17α-E2 increases hepatic IGF1 production in male mice without altering GH secretion. Representative GH pulse patterns over a 6-h period in (A) male C57BL6/n control (CON) mice at baseline, (B) male C57BL6/n mice at baseline prior to 17α-E2 treatment, (C) male C57BL6/n CON mice following the 15-wk treatment period, and (D) male C57BL6/n mice following 15 wk of 17α-E2 treatment. (E) Total GH secretion during the 6-h testing period and (F) plasma, (G) liver, (H) muscle (quadriceps), and white adipose tissue (WAT; epididymal) IGF1 protein concentrations in C57BL6/n CON and 17α-E2-treated mice following a 15-wk intervention. All data are presented as mean ± SEM and were analyzed by Student’s t test. n = 8/group.