Figure 1.
Association of the PRSs with becoming a cognitively healthy centenarian and the effect of inclusion of subsignificant variants. The top panel shows the number of variants (in log10 scale) included in each PRS (including APOE variants). The bottom panel shows the p value of the difference in PRS between the cognitively healthy centenarians and controls. Circles denote PRSs including the APOE variants and triangles denote PRSs without the APOE variants. Darker points refer to the most significant models including and excluding APOE, respectively. Known refers to the PRS including the 29 previously identified variants associated with longevity. PRS-x refers to the PRS including additional subsignificant variants depending on the p value of association of the variants in the by-proxy GWAS on longevity: PRS-8 for variants with p < 5 × 10−8; PRS-7 for variants with p < 5 × 10−7; PRS-6 for variants with p < 5 × 10−6, etc. GWAS = genome-wide association studies; PRS = polygenic risk score.