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. 2020 Nov 20;76(5):750–759. doi: 10.1093/gerona/glaa289

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© The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Association of the PRS-5 model without APOE on survival, stratified by APOE-ε4 status. The top panel shows the survival curves for individuals with high PRS and low PRS, stratified by APOE-ε4 status (dichotomized in “carriers” of APOE-ε4 allele and noncarriers) in the population controls for which follow-up data were available (N = 1620). The p value refers to the association of the PRS-5 in the multivariate Cox regression model while adjusting for gender, APOE-ε4 carriership (dichotomized), and population substructure (PCs 1–5). The lower panel shows the number of samples in each category. PRS = polygenic risk score.