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. 2021 Apr 16;12:619103. doi: 10.3389/fphar.2021.619103

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Copyright © 2021 Hao, Wu, Yuan, Gong, Huang, Ma, Zhu, Gan, Da, Deng, Li and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Xiaoyaosan on the NLRP3-ASC-CASPASE-1 pathway in the colon. (A) NLRP3mRNA in colon (n = 6). (B) ASCmRNA in colon (n = 6). (C) CASPASE-1mRNA in colon (n = 6). (D) Expression of NLRP3, ASC, CASPASE-1 protein in colon (n = 4). (E) NLRP3 protein in colon (n = 4). (F) ASC protein in colon (n = 4). (G) CASPASE-1 protein in colon (n = 4). Data are expressed as the mean ± SEM. *p < 0.05, **p < 0.01 vs. the control group; ^# p < 0.05, ^## p < 0.01 vs. the antibiotic-induced model group.