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. 2021 Apr 16;12:619103. doi: 10.3389/fphar.2021.619103

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Copyright © 2021 Hao, Wu, Yuan, Gong, Huang, Ma, Zhu, Gan, Da, Deng, Li and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Xiaoyaosan suppresses anxiolytic-like behaviors and improve depressive behavior by modulating the gut microbiota and inhibiting the excessive activation of the NLRP3 inflammasome in the colon.