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. 2021 Apr 30;7(18):eabf7390. doi: 10.1126/sciadv.abf7390

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Fig. 2 — (A) In vivo experimental protocol for the delivery of cationic LPH in GL261 glioma mouse tumor model. LPH distribution is analyzed at 10 min after LPH administration. (B) Representative contrast-enhanced T1-weighted MR images before and after MB-FUS treatment. (C) Quantification of the LPH extravasation in non–FUS-treated and FUS-treated tumor at 10 min after treatment (5.4-fold, P = 0.032). (D) Representative fluorescent microscopy data of LPH extravasation in tumor at 10 min after LPH administration. Plots show means ± SEM (N = 3). P values were determined by unpaired t tests. *P ≤ 0.05.