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. 2021 Apr 30;7(18):eabd4676. doi: 10.1126/sciadv.abd4676

Fig. 4. Subgroup-associated core regulatory circuitries in GBM.

Fig. 4

(A) Core interconnected transcriptional regulatory circuitries in each integrative subtype of GBM tissues. Core TFs are highlighted in colored circles. Key interactive partners of core TFs are indicated in gray circles. (B) Heatmap showing response of AC1-MES core TFs to a BET protein degrader (dBET6, 500 nM) treatment in U87 cells (GSE99181; transcripts per million, > 0.1). (C) Enhanced deposition of H3K27ac signals across regulatory regions of SOX2, NR2F1, ETV6, and ETS1 in GBM tissues. (D) Pathway enrichment of recurrent TFs in two coexpressed core modules across GBM subtypes.