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. 2021 Apr 13;10:e65266. doi: 10.7554/eLife.65266

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© 2021, Cobo et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 4. — (A) The magnitude of the reflex withdrawal following a mild experimental noxious stimulus (baseline reflex sensitivity) compared with the clinically required heel lance for each neonate in the Control Group (n = 18). Solid line indicates line of best fit. (B) Average electromyography (EMG) traces (top) for neonates in the Control Group (purple) and Intervention Group (blue, n = 15) where neonates were gently brushed at a rate of approximately 3 cm/s for 10 s prior to the heel lance. Dashed lines indicate the point of stimulation. Each neonate’s EMG responses to the experimental noxious stimulus and the heel lance are shown in Figure 4—figure supplement 1. (Bottom) Magnitude of the reflex withdrawal response in the two groups. Error bars indicate mean of the root mean square (RMS) of the reflex withdrawal ± standard error. (C) The magnitude of the reflex withdrawal following a mild experimental noxious stimulus (baseline reflex sensitivity) compared with the clinically required heel lance for each neonate in the Intervention Group (gentle touch) (Figure 4—source data 1).

Figure 4—source data 1. Numerical data plotted in Figure 4A,B,C.

elife-65266-fig4-data1.xlsx^{(9.9KB, xlsx)}

Figure 4—figure supplement 1. — (A) The magnitude of the reflex withdrawal following a mild experimental noxious stimulus (baseline reflex sensitivity) compared with the clinically required heel lance for each neonate in the Control Group (n = 18). Solid line indicates line of best fit. (B) Average electromyography (EMG) traces (top) for neonates in the Control Group (purple) and Intervention Group (blue, n = 15) where neonates were gently brushed at a rate of approximately 3 cm/s for 10 s prior to the heel lance. Dashed lines indicate the point of stimulation. Each neonate’s EMG responses to the experimental noxious stimulus and the heel lance are shown in Figure 4—figure supplement 1. (Bottom) Magnitude of the reflex withdrawal response in the two groups. Error bars indicate mean of the root mean square (RMS) of the reflex withdrawal ± standard error. (C) The magnitude of the reflex withdrawal following a mild experimental noxious stimulus (baseline reflex sensitivity) compared with the clinically required heel lance for each neonate in the Intervention Group (gentle touch) (Figure 4—source data 1).

Figure 4—source data 1. Numerical data plotted in Figure 4A,B,C.

elife-65266-fig4-data1.xlsx^{(9.9KB, xlsx)}