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. 2021 Apr 23;2021:6890423. doi: 10.1155/2021/6890423

Figure 2.

Figure 2

TGIF2 interacted with the TGF-β1/smad pathway. (a) Sequences of three TGIF2 siRNAs and negative control. (b) TGIF2 mRNA level after transfected by siRNAs. (c) TβR1 and TGF-β1 mRNA levels (for TβR1, TGIF2 siRNA vs. NC, P < 0.0001∗∗∗; for TGF-β1, TGIF2 siRNA vs. siRNA NC, P < 0.0001∗∗∗). Relative TβR1, TGF-β1, and p-smad2/3 protein expressions (for TβR1, TGIF2 siRNA vs. NC, P < 0.0001∗∗∗; for TGF-β1, TGIF2 siRNA vs. NC, P = 0.0047∗∗; and for p-smad2/3, TGIF2 siRNA vs. NC, P = 0.0039∗∗). (d) CK19, α-SMA, and collagen I mRNA levels between TGIF2 siRNA and NC (P < 0.0001∗∗∗, P < 0.0001∗∗∗, and P < 0.0001∗∗∗). Relative CK19, α-SMA, and collagen I protein expressions between TGIF2 siRNA and NC (P < 0.0001∗∗∗, P = 0.0002∗∗∗, and P = 0.0004∗∗∗).