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. 2021 Apr 23;2021:6890423. doi: 10.1155/2021/6890423

Figure 5.

Figure 5

miR-34a induced EMT and fibrogenesis of HIBEC. (a) Vimentin and FSP-1 mRNA levels (for vimentin, miR-34a mimics vs. NC, P < 0.0001∗∗∗; miR-34a mimics vs. inhibitor, P < 0.0001∗∗∗, and miR-34a inhibitor vs. NC, P < 0.0001∗∗∗; for FSP-1, miR-34a mimics vs. NC, P < 0.0001∗∗∗; miR-34a mimic vs. inhibitor, P < 0.0001∗∗∗; and miR-34a inhibitor vs. NC, P < 0.0001∗∗∗). (b) α-SMA and collagen I mRNA levels (for α-SMA, miR-34a mimics vs. NC, P < 0.0001∗∗∗; miR-34a mimics vs. inhibitor, P < 0.0001∗∗∗; and miR-34a inhibitor vs. NC, P < 0.0001∗∗∗; for collagen I, miR-34a mimics vs. NC, P < 0.0001∗∗∗; miR-34a mimics vs. inhibitor, P < 0.0001∗∗∗; and miR-34a inhibitor vs. NC, P < 0.0001∗∗∗). (c) Relative vimentin and FSP-1 protein expressions (for vimentin, miR-34a mimics vs. NC, P = 0.0031∗∗; miR-34a mimics vs. inhibitor, P = 0.0003∗∗∗; and miR-34a inhibitor vs. NC, P = 0.0015∗∗; for FSP-1, miR-34a mimics vs. NC, P = 0.0054∗∗; miR-34a mimics vs. inhibitor, P = 0.0004∗∗∗; and miR-34a inhibitor vs. NC, P = 0.0271∗). (d) Relative α-SMA and collagen I protein expressions (for α-SMA, miR-34a mimics vs. NC, P = 0.0047∗∗; miR-34a mimics vs. inhibitor, P = 0.0007∗∗∗; and miR-34a inhibitor vs. NC, P = 0.0083∗∗; for collagen I, miR-34a mimics vs. NC, P = 0.0023∗∗; miR-34a mimics vs. inhibitor, P = 0.0003∗∗∗, and miR-34a inhibitor vs. NC, P = 0.0006∗∗∗).