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. 2021 Apr 23;2021:6890423. doi: 10.1155/2021/6890423

Figure 6.

Figure 6

miR-34a promoted EMT and fibrosis of HIBEC through the TGF-β1/smad pathway and miR-34 upregulated inflammatory factors. (a) TβR1 and TGF-β1 mRNA levels (for TβR1, miR-34a mimics vs. NC, P < 0.0001∗∗∗; miR-34a mimics vs. inhibitor, P < 0.0001∗∗∗; and miR-34a inhibitor vs. NC, P < 0.0001∗∗∗; for TGF-β1, miR-34a mimics vs. NC, P < 0.0001∗∗∗; miR-34a mimics vs. inhibitor, P < 0.0001∗∗∗; and miR-34a inhibitor vs. NC, P < 0.0001∗∗∗). (b) IL-6 and IL-17 mRNA levels (for IL-6, miR-34a mimics vs. NC, P = 0.0002∗∗∗; miR-34a mimics vs. inhibitor, P < 0.0001∗∗∗; and miR-34a inhibitor vs. NC, P < 0.0001∗∗∗; for IL-17, miR-34a mimics vs. NC, P = 0.0002∗∗∗, miR-34a mimics vs. inhibitor, P < 0.0001∗∗∗; and miR-34a inhibitor vs. inhibitor-NC, P < 0.0001∗∗∗). (c) Relative TβR1, TGF-β1, and p-smad2/3 protein expressions (for TβR1, miR-34a mimics vs. NC, P = 0.0013∗∗; miR-34a mimics vs. inhibitor, P < 0.0001∗∗∗; and miR-34a inhibitor vs. NC, P = 0.0006∗∗∗; for TGF-β1, miR-34a mimics vs. NC, P = 0.0039∗∗; miR-34a mimics vs. inhibitor, P < 0.0001∗∗∗; and miR-34a inhibitor vs. NC, P = 0.0090∗∗; for p-smad2/3, miR-34a mimics vs. NC, P = 0.0679, ns; miR-34a mimics vs. inhibitor, P = 0.0027∗∗, and miR-34a inhibitor vs. NC, P = 0.0041∗∗). (d) Relative IL-6 and IL-17 protein expressions (for IL-6, miR-34a mimics vs. NC, P = 0.004∗∗; miR-34a mimics vs. inhibitor, P = 0.0008∗∗∗; and miR-34a inhibitor vs. NC, P = 0.0047∗∗; for IL-17, miR-34a mimics vs. NC, P = 0.0186∗; miR-34a mimics vs. inhibitor, P = 0.0028∗∗; and miR-34a inhibitor vs. NC, P = 0.0062∗∗).