Figure 1.

Effect of treatment on LDL density and distribution of lipoprotein classes. Density gradient ultracentrifugation (DGUC) (a) and relative flotation rate (Rf) (b) were performed at baseline and after 12 months of treatment to determine changes in lipoprotein class distribution and LDL peak buoyancy, respectively. We found no significant modification in LDL density (b), whereas DGUC analysis showed a significant decrease in the LDL-c subfractions together with a trend of reduction in TG-rich lipoproteins (a) (VLDL: very low-density lipoproteins; IDL: intermediate-density lipoproteins; LDL: low-density lipoproteins; HDL: high-density lipoproteins; Non-HDL-c: non-HDL cholesterol; FU: follow-up).