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. 2021 Apr 16;11:659676. doi: 10.3389/fonc.2021.659676

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Copyright © 2021 Hu, Cai, Zhao, Zhong and Gong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HNRNPC knockdown blocked HCC cell proliferation in vivo. (A) Huh-7-cell xenograft tumors in Lv-HNRNPC and Lv-NC groups. (B, C) t-test analysis showing tumor weights and sizes in Lv-HNRNPC and Lv-NC Huh-7 cell groups. (D) H&E staining to confirm xenograft tumors (upper panel); IHC to detect HNRNPC levels in xenograft tumors (middle panel); proliferation of xenograft tumors as determined by Ki-67 staining (nether panel). (E) IHC staining to analyze CD34 (upper panel), Vimentin (middle panel), and E-Cadherin (nether panel) expression in xenograft tumors. The tumor size and weight were demonstrated as mean ± standard deviation (SD). ***P < 0.001.