Figure 5.

After treatment with ML-098 (20 nmol/l), MAPK signaling pathway activation was recovered completely in Lv-HNRNPC-group cells, and proliferation ability was partially reversed. (A, B) Western blot to detect recovery of activation of the MAPK signaling pathway in Lv-HNRNPC groups after treatment with ML-098. (C, D) Colony formation assay showing the reversed efficiency of ML-098 in Lv-HNRNPC group cell proliferation. (E) CCK-8 test showing the rescue by ML-098 of cell viability in the Lv-HNRNPC group. The tests mentioned above were operated three times respectively, and the results were reported as mean ± standard deviation (SD). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, for Lv-NC+DMSO group compared with Lv-HNRNPC+ML-098 group; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001, for Lv-HNRNPC+DMSO group compared with Lv-HNRNPC+ML-098 group.