Table 2.

Chompret criteria

Chompret criteria for LFS
1. Proband diagnosed with a core LFS tumor (soft-tissue sarcoma, osteosarcoma, premenopausal breast cancer, CNS tumor, adrenocortical carcinoma) before age 46 years AND at least one first- or second-degree relative with a core LFS tumor (except breast cancer, if the proband has breast cancer) before age 56 years
2. OR a proband with multiple primary tumors (except multiple breast cancers), two of which are LFS core tumors, with the first occurring at age < 46 years
3. OR a proband with adrenocortical carcinoma, choroid plexus carcinoma, or rhabdomyosarcoma of embryonal anaplastic subtype, irrespective of family history
4. OR a proband with breast cancer < 31 years

Adapted by Bougeard et al. 2015 [28]

LFS Li-Fraumeni syndrome