Inhibition of ACE2 binding positively correlates with IgG antibodies reactive to Spike or RBD
(A−F) Serum IgG, IgM, and IgA reactive to Spike or RBD and percent ACE2 blockade from different groups of anti-S/RBD IgG-positive asymptomatic individuals and COVID-19 patients analyzed by ELISA. IgG Spike (A), IgM Spike (B), IgA Spike (C), IgG RBD (D), IgM RBD (E), and IgA RBD (F). Data were analyzed by nonlinear regression and two-tailed correlation analysis between percent ACE2 blockade with IgG, IgM, and IgA.