Table 3.

Testing of the best five proteins in discriminating patient’s vital status

Protein	AUC	Cutoff	Sensitivity	Specificity	PPV	NPV	Univariate P	Multivariate P	HR (95%CI)
4E-BP1_pT70	0.80	0.374	1	0.576	0.164	1	0.0002	NAa	NAa
Chk1_pS345	0.79	0.279	0.727	0.871	0.320	0.975	<0.0001	0.0079	9.4 (1.8–49.2)
Snail	0.77	−0.541	1	0.462	0.134	1	0.01	NAa	NAa
STAT5 alpha	0.77	1.160	0.818	0.713	0.188	0.979	0.01	0.0126	10.1 (1.6–62.5)
PAI-1	0.76	1.357	0.727	0.879	0.333	0.975	0.0001	0.0185	6.9 (1.4–34.0)
5-protein panel	0.89	4 out of 5 markers	0.818	0.954	0.600	0.984	<0.0001	0.0006	21.2 (3.7–122.2)

^aFor these cases the multivariate Cox regression cannot be fitted due to the lack of adverse events in one of the two groups obtained according to the cutoff

AUC area under the curve, PPV positive predictive value, NPV negative predictive value, HR hazard ratio, CI confidence interval, NA not available