Table 2.
Demographic and clinical characteristics of the study population with non-glomerular CKD diagnosis by baseline blood pressure percentile. Median (25th percentile, 75th percentile) or N (%).
| BP percentile <50 (N = 35) | BP percentile 50 to <75 (N = 40) | BP percentile 75 to <90 (N = 66) | BP percentile 90+ with prior HTN (N = 128) | BP percentile 90+ with no prior HTN (N = 275) | Overalla (N = 560) | |
|---|---|---|---|---|---|---|
| Age (years) | 12.5 [9.0, 14.9] | 11.0 [8.4, 12.9] | 10.4 [6.6, 13.3] | 8.7 [4.6, 12.8] | 7.4 [4.3, 11.6] | 8.6 [4.8, 12.6] |
| Male | 20 (57.1) | 20 (50.0) | 42 (63.6) | 82 (64.1) | 208 (75.6) | 383 (68.4) |
| Black Race | 5 (14.3) | 6 (15.0) | 16 (24.2) | 27 (21.1) | 53 (19.3) | 109 (19.5) |
| Hispanic Ethnicity | 2 (5.7) | 1 (2.5) | 8 (12.1) | 25 (19.5) | 40 (14.6) | 77 (13.8) |
| Height Percentile | 24.2 [7.6, 42.3] | 15.4 [7.1, 49.3] | 23.4 [7.7, 51.0] | 24.4 [7.5, 49.7] | 29.0 [8.4, 58.7] | 25.1 [7.7, 51.4] |
| Weight Percentile | 46.1 [19.2, 81.5] | 41.6 [11.0, 76.0] | 38.7 [24.3, 83.0] | 51.1 [23.8, 81.2] | 43.0 [18.2, 76.5] | 43.2 [17.9, 79.7] |
| BMI | ||||||
| <5th percentile | 2 (5.7) | 1 (2.6) | 2 (3.0) | 3 (2.4) | 15 (5.8) | 23 (4.3) |
| 5–<85th percentile | 21 (60.0) | 28 (71.8) | 44 (66.7) | 75 (61.0) | 171 (65.8) | 346 (64.8) |
| 85th-<95th percentile | 6 (17.1) | 6 (15.4) | 6 (9.1) | 17 (13.8) | 37 (14.2) | 74 (13.9) |
| ≥95 perentile | 6 (17.1) | 4 (10.3) | 14 (21.2) | 28 (22.8) | 37 (14.2) | 91 (17.0) |
| Use of Antihypertensive | ||||||
| None | 1 (2.9) | 8 (20.0) | 9 (13.6) | 16 (12.5) | 157 (74.1) | 197 (39.6) |
| Other antihypertensive | 3 (8.6) | 4 (10.0) | 13 (19.7) | 33 (25.8) | 17 (8.0) | 77 (15.5) |
| ACE-inhibitor/ARB | 31 (88.6) | 28 (70.0) | 44 (66.7) | 79 (61.7) | 38 (17.9) | 223 (44.9) |
| CKD Duration (years) | 12.3 [9.0, 14.9] | 11.0 [8.4, 12.9] | 9.4 [4.8, 13.3] | 8.0 [4.2, 11.0] | 7.2 [4.2, 10.9] | 8.1 [4.5, 12.1] |
| eGFR, (ml/min|1.73m2) | 44.3 [34.4, 50.1] | 49.8 [34.5, 64.5] | 54.6 [37.9, 63.1] | 49.1 [39.5, 66.8] | 52.3 [37.7, 62.4] | 50.3 [37.4, 62.9] |
| Urine P:C ratio | 0.2 [0.1, 0.5] | 0.2 [0.1, 0.4] | 0.3 [0.1, 1.1] | 0.2 [0.1, 0.7] | 0.4 [0.2, 0.9] | 0.3 [0.1, 0.8] |
| P:C ratio >2.0 | 3 (8.8) | 2 (5.3) | 8 (12.3) | 11 (9.1) | 15 (7.7) | 41 (8.8) |
| Household Income | ||||||
| $0-$36000/year | 16 (45.7) | 18 (46.2) | 27 (42.2) | 54 (43.5) | 65 (34.6) | 184 (39.5) |
| $36001-$75000/year | 8 (22.9) | 10 (25.6) | 17 (26.6) | 39 (31.5) | 62 (33.0) | 141 (30.3) |
| $75001/year + | 11 (31.4) | 11 (28.2) | 20 (31.2) | 31 (25.0) | 61 (32.4) | 141 (30.3) |
| Maternal education college or more | 22 (64.7) | 28 (70.0) | 43 (65.2) | 78 (62.4) | 115 (63.2) | 294 (63.5) |
| Eventsb | 10 | 9 | 28 | 53 | 89 | 194 |
a
N = 16 missing BP percentile at baseline
b
Initiation of kidney replacement therapy (dialysis or kidney transplant), or 30% decline in estimated glomerular filtration rate ACE, angiotensin converting enzyme; ARB, angiotensin receptor blocker; BMI, body mass index; BP, blood pressure; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; P:C protein:creatinine