Schematic of the ocular anatomy with drug concentrations in the aqueous humor (blue box), retina (yellow box), and choroid (red box) after topical administration of muco-inert NS formulation (green line) or clinical formulation (red line). Adapted from Schopf, et al., Copyright 2014, with permission from Springer Nature, and Schopf, et al., Copyright 2015, with permission from ARVO [60, 65].