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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Expert Opin Biol Ther. 2020 Dec 21;21(5):587–602. doi: 10.1080/14712598.2021.1862791

Figure 1. B7-H3 structure.

Figure 1.

B7-H3 is a type I transmembrane protein composed of an extracellular, a transmembrane and a short intracellular domain. Human B7-H3 exists in two isoforms as determined by its extracellular domain: 4IgB7-H3 which comprises two pairs of IgV-like and IgC-like domains (A), and 2IgB7-H3 which comprises a single pair of IgV-like and IgC-like domains (B). Murine B7-H3 comprises a single pair of IgV-like and IgC-like domains. IgV: immunoglobulin variable; IgC: immunoglobulin constant.