Table 1.

Summary of ILM structural components and their digestive enzymes

Major ILM components	Digestive Enzyme	References
collagen IV (α5α5α6)	collagenase	Bu et al., 2015
collagen IV (α3α4α5)
collagen VI
collagen XVIII
laminin (LNα1β2γ1)	pronase	Dalkara et al., 2009
laminin (LNα5β2γ1)
hyaluronic acid	hyaluronidase	Rhodes, 1982
fibronectin	dispase	Rhodes, 1982
nidogen 1	PNGase F, GluC, trypsin	Kunze et al., 2010; Lössl et al., 2014; Patel et al., 2014
perlecan	plasmin, stromelysin, collagenase	Timpl and Brown, 1996; Whitelock et al., 1996
dystroglycan	ureafaciens sialidase, beta(1,4)galactosidase, beta-N-acetylglucosaminidase, Bgus, Xylsa	Briggs et al., 2016; Clements et al., 2017; Combs and Ervasti, 2005
agrin	neurotrypsin	Kröger and Mann, 1996; Reif et al., 2007
CSPG	chondroitinase ABC	Clark et al., 2011