Table 1.
EdgeR report of differentially expressed genes 18 h post-treatment with 2 µM RK-33.
| GeneID | Name | log2 fold change | log2 counts per million | F value | p value | False discovery rate |
|---|---|---|---|---|---|---|
| ENSG00000133124 | IRS4 | −9.220240267 | 1.229125796 | 149.1749 | 2.89E−34 | 1.69E−29 |
| ENSG00000096696 | DSP | −8.484792295 | 0.549901848 | 93.17747 | 4.97E−22 | 9.65E−18 |
| ENSG00000145147 | SLIT2 | −8.122797551 | 0.215628794 | 69.49186 | 7.84E−17 | 1.14E−12 |
| ENSG00000261409 | AL035425.3 | −8.022265953 | 0.113605342 | 60.57704 | 7.19E−15 | 5.99E−11 |
| ENSG00000138829 | FBN2 | −7.721874417 | −0.141878891 | 49.16692 | 2.38E−12 | 1.39E−08 |
| ENSG00000083857 | FAT1 | −7.711916601 | −0.142206665 | 50.58668 | 1.15E−12 | 7.47E−09 |
| ENSG00000154277 | UCHL1 | −7.629659662 | −0.220071849 | 45.5358 | 1.51E−11 | 7.35E−08 |
| ENSG00000139219 | COL2A1 | −7.594048405 | −0.247211954 | 44.80238 | 2.20E−11 | 9.86E−08 |
| ENSG00000229807 | XIST | −7.425086724 | 4.779411144 | 281.6285 | 8.79E−06 | 0.013432 |
| ENSG00000089685 | BIRC5 | −7.372112695 | −0.421255852 | 38.53409 | 5.42E−10 | 2.26E−06 |
| ENSG00000116962 | NID1 | −7.05272162 | −0.69051715 | 28.24878 | 1.07E−07 | 0.000297 |
| ENSG00000038427 | VCAN | −7.017959819 | −0.727725687 | 25.70546 | 3.99E−07 | 0.000861 |
| ENSG00000176887 | SOX11 | −7.004754934 | −0.728056321 | 27.13324 | 1.91E−07 | 0.000483 |
| ENSG00000117114 | ADGRL2 | −6.95027203 | −0.766705238 | 26.38183 | 2.81E−07 | 0.000655 |
| ENSG00000054598 | FOXC1 | −6.756514098 | −0.931471077 | 19.71939 | 8.99E−06 | 0.013432 |
| ENSG00000188153 | COL4A5 | −6.756514098 | −0.931471077 | 19.71939 | 8.99E−06 | 0.013432 |
| ENSG00000197565 | COL4A6 | −6.610183248 | −1.02235097 | 19.90055 | 8.17E−06 | 0.013236 |
| ENSG00000169855 | ROBO1 | −6.551036428 | −1.069611081 | 18.62718 | 1.59E−05 | 0.021095 |
| ENSG00000170558 | CDH2 | −6.544969004 | −1.069721671 | 18.90017 | 1.38E−05 | 0.019153 |
| ENSG00000159217 | IGF2BP1 | −5.889308666 | 0.348421941 | 64.80318 | 8.72E−16 | 1.02E−11 |
| ENSG00000135862 | LAMC1 | −5.486512767 | 0.002490741 | 48.29217 | 3.71E−12 | 1.97E−08 |
| ENSG00000102024 | PLS3 | −4.323906265 | 1.49827749 | 117.2158 | 3.02E−27 | 8.81E−23 |
| ENSG00000171246 | NPTX1 | −3.992292706 | −0.550303193 | 23.25519 | 1.42E−06 | 0.002675 |
| ENSG00000154734 | ADAMTS1 | −3.971030294 | 0.580596315 | 60.82655 | 6.34E−15 | 5.99E−11 |
| ENSG00000145555 | MYO10 | −3.696600515 | −0.303481708 | 26.65852 | 2.44E−07 | 0.000592 |
| ENSG00000154380 | ENAH | −3.64365296 | −0.274861002 | 25.06365 | 5.59E−07 | 0.001124 |
| ENSG00000142949 | PTPRF | −3.553235332 | −0.021528142 | 33.79895 | 6.35E−09 | 1.95E−05 |
| ENSG00000163430 | FSTL1 | −3.20753747 | −0.332407149 | 22.31002 | 2.33E−06 | 0.003987 |
| ENSG00000117399 | CDC20 | −3.098292124 | −0.420984699 | 17.47004 | 2.92E−05 | 0.034778 |
| ENSG00000176788 | BASP1 | −3.03195077 | −0.24810378 | 22.38461 | 2.24E−06 | 0.003952 |
| ENSG00000111206 | FOXM1 | −3.015861999 | 0.001271235 | 28.7242 | 8.38E−08 | 0.000244 |
| ENSG00000046604 | DSG2 | −2.684610226 | 0.484772447 | 34.90713 | 3.48E−09 | 1.19E−05 |
| ENSG00000101057 | MYBL2 | −2.316037106 | 0.025267442 | 17.38763 | 3.06E−05 | 0.035688 |
| ENSG00000148773 | MKI67 | −1.384356143 | 1.091562301 | 18.66531 | 1.56E−05 | 0.021095 |
| ENSG00000083444 | PLOD1 | −1.18441556 | 1.399169378 | 17.50631 | 2.88E−05 | 0.034778 |
| ENSG00000131747 | TOP2A | −1.054906153 | 1.866051914 | 19.13111 | 1.25E−05 | 0.017772 |
| ENSG00000204388 | HSPA1B | −0.741213605 | 3.325135537 | 27.77549 | 1.39E−07 | 0.000367 |
| ENSG00000178429 | RPS3AP5 | 2.015230135 | 1.279297836 | 36.33718 | 3.41E−09 | 1.19E−05 |
| ENSG00000234648 | AL162151.2 | 4.827847593 | 0.344327701 | 50.73859 | 1.07E−12 | 7.47E−09 |
Differential expression and p values are calculated for each gene using an exact test analogous to Fisher’s exact test adapted for overdispersed data in the EdgeR package88.