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. 2021 Apr 30;12:2474. doi: 10.1038/s41467-021-22625-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Pathway enrichment analysis of IPA canonical pathways overrepresented in differentially expressed genes across all three cohorts. Pathways are ranked by mean activation $z$ -score, with point size scaled by Fisher’s exact test p values. B Geneset enrichment analysis (GSEA) against the Reactome pathway database. Pathways are ranked by the number of cohorts the pathway was enriched in, then by the mean FDR-adjusted p value across cohorts. GSEA p values are derived from permutation testing, and corrected for multiple testing using the FDR method. In both panels, gene sets containing PTK2 and/or ITGB3 are highlighted in bold and italic.