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. 2021 Apr 30;12:2474. doi: 10.1038/s41467-021-22625-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A–C Volcano plots of differentially expressed genes for the AML PMP (A), TCGA LAML (B), and Beat AML (C) cohorts. Genes with absolute log₂fold-change of 1 and FDR-adjusted p ≤ 0.1 (based on Wald tests as implemented in DESeq2) are highlighted in red (over-expressed in third-tercile APS) and blue (over-expressed in first-tercile APS). D Comparison of differentially expressed genes between cohorts. All genes which were differentially expressed in any single cohort are displayed with their log2FoldChange values across all cohorts. The top 40 over-expressed and bottom ten under-expressed genes (by mean fold-change across cohorts) are labeled.