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. 2021 Apr 30;11:9371. doi: 10.1038/s41598-021-88585-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Unsupervised cluster analysis of protein and transcript alterations in uterine leiomyomas (ULMs) from Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) and non-syndromic (NS) patients. Heatmaps detail (A) transcripts and (B) proteins quantified exhibiting a median absolute deviation (MAD) in total RNA-seq (MAD > 1) or TMT-10 quantitative proteomics (MAD > 0.5) data; clusters organized by correlation and average linkage (ClustVis). Plots reveal one HLRCC patient, designated as 1805, clustering as a non-syndromic ULM.