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. 2021 Apr 30;11:9371. doi: 10.1038/s41598-021-88585-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Protein interaction network enriched from validated transcripts confirmed at the protein-level as altered between HLRCC versus non-syndromic (NS) ULMs. Validated transcripts confirmed at the protein level (51 total) were analyzed using MetaScape⁵¹ and resulting protein–protein interaction networks enriched by proteins elevated (highlighted in green) or decreased (heighted in red) in HLRCC vs NS ULMs were assembled using Cytoscape⁵². The top pathways enriched by network proteins are also noted.