Table 4.
Peptides quantified in HLRCC versus NS ULMs encoding functionally characterized 2-succinyl modified cysteine residues.
| Gene name | HLRCC vs NS | P-value | HLRCC vs NS ULM | Protein name | Modified | Impact of cysteine modification | Citation |
|---|---|---|---|---|---|---|---|
| (Median LogFC) | (MWU) | (n cases quantified) | Cysteine | (Pubmed ID) | |||
| CLIC1 | 2.78 | < 0.0001 | 15_13 | Chloride intracellular channel protein 1 | C24 | Loss of dimerization and of ion transport activity | 14613939 |
| MGST3 | 2.56 | < 0.0001 | 15_13 | Microsomal glutathione S-transferase 3 | C150 | Abolishes S-acylation; when associated with S-151 | 21044946 |
| PRDX5 | 0.51 | 0.4 | 4_3 | Peroxiredoxin-5, mitochondrial | C204 | Complete loss of protein activity | 10751410 |
| NFKB1 | 0.479 | N/A | 5_1 | Nuclear factor NF-kappa-B p105 subunit | C61 | Suppresses S-nitrosylation-induced inhibition of DNA-binding activity | 11466314 |
| CKB | 0.263 | 0.22 | 10_10 | Creatine kinase B-type | C283 | Complete loss of protein activity | 8186255 |
2SC modified PSMs elevated in HLRCC versus NS ULMs, denotes total number of ULMs candidates PSMs were quantified in, n# cases quantified, as well as specific residue, impact on protein function and supporting citations (Pubmed ID).