Table 1.
UTMOST Single tissue analysis (Brain tissues).
| Loci | Location hg19 | MinP (UTMOST) | Tissue | Z score | SNPs in model | Other associations GWAS, GBA and/or TWAS |
|---|---|---|---|---|---|---|
| PTPRE | chr10:129705325-129884164 | 1.53 × 10−6 | Brain cortex | −4.8 | 6 | – |
| CIPC* | chr14:77564601-77583630 | 3.82 × 10−6 | Brain hipoccampus | −4.62 | 19 | – |
| NKX2-2 | chr20:21491660-21494664 | 9.38 × 10−9 | Brain nucleo accubens basal ganglia | −5.74 | 62 | Grove et al./Alonso-Gonzalez et al. |
| PINX1* | chr8:10622884-10697299 | 3.82 × 10−6 | Brain nucleo accubens basal ganglia | 4.62 | 14 | Grove et al./Alonso-Gonzalez et al. (neighbour gene C8orf74) |
List of independent significant loci.
Bonferroni threshold <3.85 × 10−6.
GWAS genome-wide association study, SNP single nucleotide polymorphism, TWAS transcriptome-wide association study.
*Marginally significant.